Insemination is procedure in which the sperm are “washed” and placed directly inside the uterus with a catheter after the egg is released from the ovary (ovulation). Insemination significantly improves pregnancy rates and can double the chances for getting pregnant in cycles in which clomiphene (Clomid) or Letrozole (Femara) is used. Insemination can be used as a treatment for male factor infertility or for patients or couples that do not have a male partner. In cases where a sperm donor will be used, the sperm donor will undergo a semen analysis, evaluation for infections, and psychological screening. The sperm donor can be selected through a sperm donor agency or can be a known sperm donor.