Medications Used with Fertility

Progesterone Injections

Progesterone injections may be recommended by your doctor during an In Vitro Fertilization Cycle (IVF) or as part of a Frozen Embryo Transfer (FET) cycle. Progesterone is a hormone made by the ovary that supports the pregnancy during the first 8 to 9 weeks until the pregnancy itself (the placenta) makes progesterone. The use of progesterone after transfer of the embryos back to the uterus during an IVF cycle has been shown to increase pregnancy rates an additional 20%. Progesterone is also used in frozen (cryopreserved) embryo transfer cycles after the uterine lining (endometrium) is sufficiently prepared (thickened) with estrogen. Progesterone prepares the uterine lining (endometrium) to “accept” the embryos and allow them to implant. Progesterone injections come in sesame oil in a multi-dose vial.



For instructions on using Progesterone Injections, please click on the following link


Projesterone capsules

Progesterone capsules may be recommended by your doctor during an In Vitro Fertilization Cycle (IVF) or as part of a Frozen Embryo Transfer (FET) cycle. Progesterone is a hormone made by the ovary that supports the pregnancy during the first 8 to 9 weeks until the pregnancy itself (the placenta) makes progesterone. The use of progesterone after transfer of the embryos back to the uterus during an IVF cycle has been shown to increase pregnancy rates an additional 20%. Progesterone is also used in frozen (cryopreserved) embryo transfer cycles after the uterine lining (endometrium) is sufficiently prepared (thickened) with estrogen. Progesterone prepares the uterine lining (endometrium) to “accept” the embryos and allow them to implant. Progesterone capsules are oral capsule than can be
inserted and absorbed vaginally.


 

Endometrin (Progesterone suppository)

Progesterone suppositories may be recommended by your doctor during an In Vitro Fertilization Cycle (IVF) or as part of a Frozen Embryo Transfer (FET) cycle. Progesterone is a hormone made by the ovary that supports the pregnancy during the first 8 to 9 weeks until the pregnancy itself (the placenta) makes progesterone. The use of progesterone after transfer of the embryos back to the uterus during an IVF cycle has been shown to increase pregnancy rates an additional 20%. Progesterone is also used in frozen (cryopreserved) embryo transfer cycles after the uterine lining(endometrium) is sufficiently prepared (thickened) with estrogen. Progesterone prepares the uterine lining (endometrium) to “accept” the embryos and allow them to implant. Endometrin comes as a tablet with a vaginal applicator.

 


Crinone (Progesterone gel)

Progesterone gel may be recommended by your doctor during an In Vitro Fertilization Cycle (IVF) or as part of a Frozen Embryo Transfer (FET) cycle. Progesterone is a hormone made by the ovary that supports the pregnancy during the first 8 to 9 weeks until the pregnancy itself (the placenta) makes progesterone. The use of progesterone after transfer of the embryos back to the uterus during an IVF cycle has been shown to increase pregnancy rates an additional 20%. Progesterone is also used in frozen (cryopreserved) embryo transfer cycles after the uterine lining (endometrium) is sufficiently prepared (thickened) with estrogen. Progesterone prepares the uterine lining (endometrium) to “accept” the embryos and allow them to implant. Crinone 8% comes as pre-packaged gel in a vaginal applicator.

 

Estradiol (Estrogen)

In patients who have undergone an In Vitro Fertilization cycle and have frozen (cryopreserved) embryos to be transferred, estradiol pills are given to prepare (thicken) the uterine lining (endometrium) to receive the embryos. Once the endometrium is sufficiently prepared (thickened) as determined by ultrasound and laboratory evaluation (estradiol or E2 levels), patients are started on progesterone prior to transfer of the embryos. In patients known to have a poor response to In Vitro Fertilization previously or who have decreased ovarian function, an estradiol patch or pill (Estrace) may be prescribed at the beginning of a treatment cycle to allow for a better response to Injectable Fertility Medications that stimulate the ovary (Gonal F, Follistim, Menopur, Repronex).



 

Metformin

Metformin is a medication used to treat and lower high blood sugar (Hyperglycemia or Diabetes Mellitus). It works by decreasing the amount of sugar released by the liver, decreasing the amount of sugar absorbed in the intestine and by allowing insulin (a hormone) to remove sugar more effectively from the bloodstream. Patients with risk factors for diabetes, including Polycystic Ovarian Syndrome (PCOS), may have their sugar levels checked and if elevated, be prescribed metformin. Metformin is commonly used to help patients with PCOS and infertility ovulate more easily and frequently on their own or when they are taking fertility medication. Patients who take metformin may also lose 5% of their body weight which also improves ovulation. In patients with Diabetes Mellitus, metformin can help
reduce the risk of having a baby with birth defects by lowering sugar levels prior to getting pregnant (conceiving).


 

Dexamethasone

Dexamethasone is used in patients with Polycystic Ovarian Syndrome (PCOS) in combination with Clomiphene in patients who don’t respond to Clomiphene alone. Dexamethasone is believed to suppress hormone levels (DHEAS) produced from the adrenal gland (endocrine gland above the kidneys) and enhance ovulation.